There are two sizes of 300A mixers, 300A-20 and 300A-70. The larger size is good for about 300 hp and the smaller one for around 250 hp. We put together
some dual mixer kits with 300's when I still had the dual 300 adapters. One went on a GM 454 crate engine(425 hp) and the other went on a strong Ford 460
engine. Both run very well. They are good mixers.
So to answer your question, yes running two of them would out perform one 425 mixer.