http://www.high-impact.net/wheels/backspacingillustration.htm#Illustration: Backspacing / Reversed Shell
Heres a diagram of what I'm talking about.
Edit: well thats the page it's on the diagram is at the bottom of the page.
Ok, we're talking about the same thing.
I wasn't aware that any beadlock manufacturers made beadlocks that were "reverse center" wheels...
If you look at the diagram you linked to, you can see why. Normally, the wide area where the bead seats is on the back, which makes the bead hard to pop off the bead seat on the back side of the rim... since it has a long way to move until it really loses the bead. The beadlock goes on the front, because the actually bead seat there is smaller/not as wide and is easier to break loose by simply having pressure in the right place on the tire.
To simply answer the originaly question: yes, if the narrower part is on the back of the rim (reverse center), then you will lose the bead on that side easier. Of course, it's marginally less likely because it's on the inside of the wheel, but it would still be a weak point.
I wouldn't buy beadlocks that were "reverse center", I would consider them a waste of money, because the beadlock would be on the side of the rim that is less likely to lose a bead to begin with, and not where it's really needed. Not to mention how much harder it would be (if not impossible) to mount tires on them.
Can you link to a specific beadlock mfg'er's site where they have "reverse center" beadlocks?