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Have you tried putting it into Tow/haul mode? I think 2500's have them. I know on my 1500 that changes some things in the transmission and could help you in troubleshooting. Are you running the tunes that came with your programmer? I bought mine through Diablewtune.com and you send him some data logs and he builds you a full custom tune and can change around a lot more stuff and it really opened my truck up even more.