Are you thinking about using a 4l60 or 4l60E?
I would argue that the 4l60E has a considerably stronger bellhousing than the th400/th350, it bolts on 360 degrees and has additonal ribbing and gusseting on it.
Also, the tailhousing of the 4l60E is a larger 6-bolt pattern and you can buy a "shorty" adapter from advance adapters.
I would also look into the 4l65E from behind the newer 6.0ls, they are supposedly beefed up for the now 350-400hp factory motors.
Are you going to run a newer LS motor or? Tranny choice would be affected alot by what you are going to run in front of it.