not all NV4500's are the same... chevy's have smaller parts then the dodges.
Like what?
The Dodge HD version used a larger diameter input shaft to handle the torque of the CTD. But if you want to keep the overall length of drivetrain down, you will want to use the shorter and still plenty strong GM style input shaft.
I think that the mainshaft on the GM version ends in a larger diameter, stronger 32 spline manner than does the Dodge 29 or 23 spline versions.
Other than that and the early GM 6.34:1 1st gear models, the guts are all the same and are interchangeable between the different versions as far as I am aware.
I would not have any concerns about running an NV4500 from a GM truck. In fact I have one that will be used to back up the 401 going into my Scrambler in an upcoming swap (although I will have to swap mainshafts so that the Dana 300 will bolt up).
I think it will be worth it. I really like the way the one in my Dodge drives. I wanted a strong transmission that I won't have to worry about, shifts smoothly, and does not have long clunky throws like a T-18. The OD is just icing on the cake as far as I am concerned.