I'm running a stock 6.0 with custom dyno tune, 295 horsepowers to the ground. Front axle, I've twisted 35 spline 4340 foote stub shafts on 39" krawlers. I've also broken a 35 spline CTM 300m stub shaft on 43' stickies. Broken probably 3 factory GM 14 bolt shafts in the rear. So far so good on 40 spline brand (mark williams) 4340 stock replacement shafts. IMO, talking front axles, if you're running what you have already (dana 60 hp or lp) 35 spline 300m will probably hold up for most folks with out big hp.
I also agree that 4340 40 spline is superior to 35 spline 300m. As long as we're talking quality shaft material in both cases.